Specific gene variants (PAM gene) cause GLP-1 resistance in 1 in 10 people, reducing the efficacy of type 2 diabetes drugs.

Background Patients with coexisting heart failure (HF) and diabetes mellitus are often prescribed complex treatment regimens, ...

Findings suggest that regular physical activity and adequate sleep may lower dementia risk, emphasizing the need for evidence-based lifestyle guidelines.

Objective To examine associations between participants’ perinatal factors, including harmonised birth weight and length, ...

5 Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China Correspondence to Dr Xianhui Qin, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou ...

Gene editing has emerged as a powerful approach for targeting the genetic causes of disease, but getting the editing ...

Nearly 1 in 4 patients with atrial fibrillation who experience an ischaemic stroke despite oral anticoagulation have ...

DNA does not float freely in the cell. Instead, it is wrapped around histone proteins to form structures called nucleosomes.

SGLT2 inhibitor therapy is linked to an increased risk for diabetic ketoacidosis in adults with T2D, particularly among those ...

The gene editing treatment targets the relatively common 1717-1G>A splicing mutation, which does not respond to many current CF therapies.

Introduction Reduced exercise performance is common in patients with repaired tetralogy of Fallot (rToF) and relates to ...