The nuclear pore complex (NPC) is an essential, highly dynamic macromolecular assembly embedded in the nuclear envelope that orchestrates the precise exchange of proteins, RNA and other macromolecules ...

Nuclear pore complexes are more dynamic than previously thought, reshaping our understanding of a vital transport process in cells. An international study led by the University of Basel (Switzerland) ...

In situ model of the nuclear pore complex transport barrier: Tethered within the pore are highly dynamic protein threads termed FG Nups (green). Under physiological conditions, cargo-carrying ...

Composite structure of the symmetric core of the nuclear pore complex, shown in a cartoon representation. The composite structure was generated by sequential unbiased searches for each protein subunit ...

Nuclear pore complexes in the nuclear membrane not only control the transport of molecules into and out of the nucleus--they play an essential role in the survival of T cells. A new study by Sanford ...

Just as cities must carefully manage the flow of cars in and out of downtown, cells regulate the movement of molecules into and out of the nucleus. This microscopic metropolis relies on an intricate ...

An international study led by the University of Basel has discovered that nuclear pore complexes—tiny gateways in the nuclear membrane—are not rigid or gel-like as once thought. Their interiors are ...

If the cell nucleus is like a bank for DNA, nuclear pores are the security doors around its perimeter. Yet more security doors aren't necessarily better: some cancer cells contain a dramatic excess of ...

Researchers at Kanazawa University report in Cell Reports how alterations in the nuclear pores lead to the degradation of anti-tumor proteins. Several types of cancer are believed to be linked to ...